September is Pulmonary Fibrosis Awareness Month, a month to bring awareness to pulmonary fibrosis (PF), which is a disease in which the lungs become scarred. PF can lead to progressive decline in lung function, and idiopathic pulmonary fibrosis (IPF) is a type of PF with no known cause or cure. IPF affects approximately 128,000 people in the US annually, with about 48,000 new diagnoses each year, and 40,000 deaths attributed to the disease.
Diagnosing PF can be a lengthy process from the time of symptom onset to official diagnosis. Methods of diagnosing PF include chest imaging, such as X-rays and computed tomography (CT) scans, in which clinicians can look at lung structure and scar tissue. Other diagnostic methods include pulmonary function tests, exercise tests, six-minute walk tests, and lung biopsies.
Early detection of PF is really important, so understanding the symptoms is crucial so that patients are able to seek a diagnosis as soon as possible. Common symptoms of PF include a persistent cough that lasts more than three months, shortness of breath, ongoing fatigue, and unintended weight loss.
Currently, treatment options for PF primarily aim to slow disease progression rather than reverse lung damage and scarring. The anti-fibrotic medications, pirfenidone and nintedanib, are approved therapies that target the biological processes involved in lung scarring. Additionally, oxygen therapy is needed in many PF cases, because as the disease progresses, the patient’s lungs will get smaller and stiffer, and oxygen levels will begin to decrease.
Currently, the only cure for PF is a lung transplant. However, the operation is complicated and comes with many risks, and some patients may not be eligible for a lung transplant. While many other treatment options are available, none stop the disease, and thus the need for new treatment options is critical.
See Also:
There are several promising new treatment options under investigation, including FIBRONEER by Boehringer Ingelheim, which is showing potential in clinical trials for slowing lung scarring and reducing inflammation. Bexotegrast is an oral medication by Pliant Therapeutics currently being tested to reduce lung fibrosis over 52 weeks, and ifetroban is in a Phase II study, being evaluated for its ability to prevent and resolve lung fibrosis.
How well do you really know your competitors?
Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.
Thank you!
Your download email will arrive shortly
Not ready to buy yet? Download a free sample
We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form
By GlobalDataPF poses significant challenges due to its rapid progression and high mortality rates. While current treatments provide some hope, ongoing research into new therapies offers potential for better management and outcomes for patients.
Related Company Profiles
Boehringer Ingelheim International GmbH
Pliant Therapeutics Inc