Axonics has been granted a patent for an implantable pulse generator that can deliver electrical pulses to a specific region within a patient’s body. The device includes a current source/sink generator with a current drive differential amplifier, allowing for selective current sourcing or sinking. The system also features a rechargeable power supply and stimulation circuitry within a hermetically sealed housing. GlobalData’s report on Axonics gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Axonics, neuromodulation implants was a key innovation area identified from patents. Axonics's grant share as of September 2023 was 55%. Grant share is based on the ratio of number of grants to total number of patents.
Implantable neurostimulator system for delivering electrical pulses to target region
A recently granted patent (Publication Number: US11766568B2) describes an implantable neurostimulator system for delivering electrical pulses to a specific region within a patient's body. The system includes an implantable lead with multiple electrodes positioned near the target region to provide electrical stimulation. It also includes an implantable pulse generator that is electrically connected to the lead.
The pulse generator consists of a biocompatible housing with a hermetically sealed internal volume. Within this volume, there is a rechargeable power supply and stimulation circuitry. The stimulation circuitry is responsible for generating the electrical pulses and is connected to the rechargeable power supply. It includes a first differential amplifier that selectively sources or sinks current to the lead, depending on the desired electrical pulse generation.
The patent also mentions a second differential amplifier within the stimulation circuitry that can selectively source or sink current to the lead. This second differential amplifier is designed to work in conjunction with the first differential amplifier. When the first differential amplifier sources current to one electrode on the lead, the second differential amplifier sinks current from another electrode. Conversely, when the first differential amplifier sinks current from one electrode, the second differential amplifier sources current to another electrode.
The first differential amplifier has inputs connected to a current command and a constant voltage supply. The current command supplies a voltage within a specific range to the non-inverting input of the first differential amplifier. The inverting input is connected to the constant voltage supply. The difference in voltage between the maximum and minimum values of the supplied voltage range is at least 5 volts.
The constant voltage supply, which is between the maximum and minimum values of the supplied voltage range, is directly or indirectly coupled to the inverting input of the first differential amplifier. This configuration allows the first differential amplifier to selectively source or sink current based on the voltage supplied by the current command.
The implantable neurostimulator system also includes a load path that connects the output of the first differential amplifier to the lead. This load path includes a sensing resistor and a voltage sensor to measure the voltage drop across the resistor. The voltage sensor consists of a current sense differential amplifier with inputs connected to the load path.
Overall, this patent describes a neurostimulator system with specific circuitry configurations that allow for precise control of electrical pulse generation and delivery to targeted regions within a patient's body.