ClearPoint Neuro has been granted a patent for an intrabody fluid transfer system. The system includes a plunger assembly and a cannula assembly, allowing fluid to be loaded into the cannula while the stylet is withdrawn to create a vacuum and define a flow channel. GlobalData’s report on ClearPoint Neuro gives a 360-degree view of the company including its patenting strategy. Buy the report here.

Smarter leaders trust GlobalData


Data Insights ClearPoint Neuro Inc - Company Profile

Buy the Report

Data Insights

The gold standard of business intelligence.

Find out more

According to GlobalData’s company profile on ClearPoint Neuro, transcranial ultrasound was a key innovation area identified from patents. ClearPoint Neuro's grant share as of September 2023 was 46%. Grant share is based on the ratio of number of grants to total number of patents.

Fluid transfer system with front-loading capability using vacuum

Source: United States Patent and Trademark Office (USPTO). Credit: ClearPoint Neuro Inc

A recently granted patent (Publication Number: US11707569B2) describes an intrabody fluid transfer system for delivering medication to a patient. The system includes a cannula assembly with a luer connector and an open channel extending through it. A plunger assembly is coupled to the cannula assembly and includes a stylet that extends into the open channel. The stylet can be retracted and extended relative to the cannula assembly to create a vacuum, allowing fluid to be front-loaded into the open channel.

In one embodiment, the distal end of the stylet extends flush with or out of the distal end of the cannula assembly when in a ready to intake fluid or fully injected position. The fluid is held for dispensing only in the fluid channel, which is located between the distal end of the cannula assembly and a medial portion of the cannula assembly.

The plunger assembly further includes a luer connector with an internal seal that provides a fluid-tight seal for a segment of the stylet. A support body is coupled to the luer connector and surrounds a sub-segment of the stylet. The plunger and stylet move together as a unit, with a second segment of the plunger residing closer to the luer connector of the plunger assembly and the luer connector of the cannula assembly in a first position.

The system may also include a drive screw as the drive member, a collar for translating the stylet, and a support tube inside the support body for retracting and extending the stylet. The stylet can be made of an MRI compatible material, such as Nitinol or fused silica, and has a length outside the support body ranging from 6 inches to 10 feet. The fluid channel has a length ranging from 1 cm to 30 cm.

Another embodiment of the invention is an intrabody fluid medication system that includes the same components as the fluid transfer system but also includes a fluid medication held in the fluid holding channel for delivery to a patient. The drive member in this system is a plunger, and there is a clearance between the cannula assembly and the stylet ranging from 0.00005 inches to 0.10 inches. An internal seal above the fluid holding channel provides a fluid-tight seal between a segment of the stylet and the cannula assembly.

Overall, this patent describes an intrabody fluid transfer system and an intrabody fluid medication system that allow for controlled delivery of fluids to a patient. The systems utilize a vacuum created by retracting the stylet to front-load fluid into the open channel of the cannula assembly.

To know more about GlobalData’s detailed insights on ClearPoint Neuro, buy the report here.

Data Insights


The gold standard of business intelligence.

Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.