Idexx Laboratories. has been granted a patent for a method to calibrate photometer sensitivity. This involves measuring the absorbance spectrum of a diluted control solution, linearly regressing the data, and comparing the slope to known reference solutions to determine chromophore concentration. GlobalData’s report on Idexx Laboratories gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Idexx Laboratories, was a key innovation area identified from patents. Idexx Laboratories's grant share as of July 2024 was 51%. Grant share is based on the ratio of number of grants to total number of patents.
Method for calibrating photometer sensitivity using absorbance spectra
The granted patent US12050171B2 outlines a method for calibrating the sensitivity of a photometer, specifically utilizing a double-beam spectrophotometer to measure the absorbance spectrum of a control solution containing a control substance. The process involves linear regression of the absorbance spectrum over a predetermined wavelength range, followed by a comparison of the slope of this spectrum to a range of slopes derived from absorbance spectra of various reference solutions, which are known to contain specific concentrations of chromophores. If the slope of the control solution falls within the established range, the concentration of the chromophore in a reference solution is calculated to match the slope of the control solution.
The patent further details that the reference solutions may include diluted blood samples, with oxygenated hemoglobin identified as a common chromophore. The control substance can be a dye, such as malachite green or crystal violet, and the method allows for adjustments to the control solution if the initial slope does not meet the criteria. Additionally, the patent specifies that both the control and reference solutions should be diluted at the same ratio, and it sets forth criteria for accepting the absorbance spectra based on coefficients of variation and determination thresholds. A secondary method is also described for calculating the concentration of a chromophore in a target solution, which involves measuring the absorbance of the control solution and using it to determine the expected absorbance of a standard solution, ultimately leading to the calculation of the chromophore concentration in the target solution.
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