Pacific Biosciences of California has filed a patent for arrays of integrated analytical devices that can analyze highly multiplexed optical reactions at high densities. The devices have an integrated diffractive beam shaping element that allows for the spatial separation of light emitted from the reactions. GlobalData’s report on Pacific Biosciences of California gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Pacific Biosciences of California, Optoelectronic biosensors was a key innovation area identified from patents. Pacific Biosciences of California's grant share as of September 2023 was 56%. Grant share is based on the ratio of number of grants to total number of patents.
Arrays of integrated analytical devices for highly multiplexed optical reactions
A recently filed patent (Publication Number: US20230314325A1) describes an array of integrated analytical devices. Each device in the array consists of a nanoscale emission volume, a detector layer, a lens element layer, and a dark mirror element. The nanoscale emission volume contains an emitter that emits a signal light. The lens element layer directs the signal light to a sensing region on the detector layer. The dark mirror element reduces the transmission of non-signal light to the sensing region.
The dark mirror element can absorb the non-signal light or have a dark mirror coating on an area of the device that does not pass the signal light. It can also have a dark mirror coating on a scattering surface or be angle-sensitive. The dark mirror element displays low reflectivity of the non-signal light and can be made of materials such as Cr or TaN.
The detector layer in each device comprises multiple sensing regions, and the lens element layer includes a diffractive beam shaping element. The array may also include a color filtration layer between the lens element layer and the detector layer. This color filtration layer consists of multiple color filtration elements, each specific for a range of light wavelengths and optically coupled to one sensing region. The diffractive beam shaping element spatially separates the signal light into multiple beams and directs them through the color filtration elements onto the sensing regions.
Additionally, the array may include an aperture layer between the nanoscale emission volume and the detector layer. This aperture layer reduces the transmission of non-signal light to the sensing region and can be made of materials like titanium nitride.
The array of integrated analytical devices can further include an excitation source, such as a waveguide excitation source, and an analyte disposed within the nanoscale emission volume. The analyte can be a biological sample.
The patent claims that the array can have at least 1,000, at least 10,000, at least 100,000, at least 1,000,000, or at least 10,000,000 nanoscale emission volumes.
In summary, the patent describes an array of integrated analytical devices that utilize nanoscale emission volumes, detector layers, lens element layers, dark mirror elements, and aperture layers to selectively detect and analyze signal light while reducing the interference from non-signal light. The array can be used for various applications, including the analysis of biological samples.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
