Quanterix has been granted a patent for methods and systems that enhance the dynamic range of assays for measuring analyte concentrations in fluid samples. The approach involves spatially segregating analytes, using capture objects, and employing detection methods to quantify analyte presence based on immobilized labeling agents. GlobalData’s report on Quanterix gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Quanterix, Laboratory automation robots was a key innovation area identified from patents. Quanterix's grant share as of June 2024 was 49%. Grant share is based on the ratio of number of grants to total number of patents.
Method for measuring analyte concentration in fluid samples
The patent US12019072B2 outlines a method for quantifying the concentration of analyte molecules or particles in a fluid sample. The process begins by exposing capture objects, which possess a binding surface with affinity for specific analytes, to a solution that may contain these analytes. As a result, some capture objects associate with the analytes. Subsequently, a binding ligand is linked to these analytes, followed by exposure to a precursor labeling agent that converts into an immobilized labeling agent at or near the capture object. The method includes addressing the capture objects to detect the presence of the immobilized labeling agent, ultimately allowing for the determination of analyte concentration based on the number of capture objects associated with the labeling agent.
Further claims detail enhancements to the method, such as spatial segregation of capture objects into separate locations, which can be reaction vessels or regions on a planar surface. The patent specifies that these locations can contain single capture objects and that the fluid sample can originate from various biological sources. The labeling agent may be insoluble under the method's conditions, and the binding ligand can include enzymatic components. Additionally, the precursor labeling agent may consist of nucleic acids, which can be amplified through specific techniques. The method also incorporates statistical analysis, such as Poisson distribution, to refine concentration measurements based on the observed associations of capture objects with the labeling agent. Overall, the claims present a comprehensive approach to analyte detection and quantification in fluid samples.
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