Repligen has patented a method for filtering fluids using tangential flow depth filtration (TFDF) systems with tubular depth filters (TDF). The method involves passing fluid through TDF units in a non-laminar flow, improving filter fluxes and reducing fouling. GlobalData’s report on Repligen gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Repligen, rtRNA virus peptides was a key innovation area identified from patents. Repligen's grant share as of May 2024 was 37%. Grant share is based on the ratio of number of grants to total number of patents.
Improved tangential flow depth filtration system with tubular depth filters
A recently granted patent (Publication Number: US11958018B2) discloses a method for filtering fluids using a specialized filter system. The method involves passing the fluid through a filter containing tubular depth filter units (TDF) with specific dimensions and characteristics. The fluid flow through the TDF is non-laminar, allowing for effective filtration. The permeate collected from the filter contains significantly lower concentrations of non-desired species compared to the original fluid, making it suitable for various applications.
Furthermore, the method includes specific parameters such as feed velocity, inner diameter of the TDF, and Reynolds number to optimize the filtration process. By adjusting these parameters, the method ensures the retention of non-desired species while allowing desired species to pass through into the permeate. The TDF is designed to retain a variety of non-desired species, including those of mammalian, microbial, and viral origin, proteins, nucleic acids, polysaccharides, and their complexes. The method also involves removing permeate from the fluid to increase the concentration of desired species retained by the TDF, resulting in a more concentrated and purified product. Overall, this patented method offers a novel approach to fluid filtration, particularly in applications such as cell culture media processing, with specific operational conditions to enhance filtration efficiency and product quality.
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