Revvity. has filed a patent for quantitative assays to assess duplex unwinding efficiency or strand exchange efficiency during isothermal amplification. The method involves providing a sample with pre-annealed duplex nucleic acids, incubating under amplification conditions, and detecting labels. GlobalData’s report on Revvity gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Revvity, Laboratory automation robots was a key innovation area identified from patents. Revvity's grant share as of January 2024 was 56%. Grant share is based on the ratio of number of grants to total number of patents.
Method for detecting unwinding or strand exchange in nucleic acids
A patent application (Publication Number: US20240018578A1) discloses a method for detecting unwinding or strand exchange of a double-stranded nucleic acid. The method involves providing a sample containing a pre-annealed duplex with a target nucleic acid, a synthetic nucleic acid with optional detectable labels, a primer with a detectable label, an amplifying enzyme, and an unwinding enzyme. The sample is then incubated under isothermal conditions for nucleic acid amplification, followed by detecting the labels present. The synthetic nucleic acid can act as an initial primer, and the method includes steps for extending the primer, unwinding the extension product, annealing the primer to the target nucleic acid, and detecting the labels.
Furthermore, the method includes additional steps such as unwinding the duplex, annealing the primer to the target nucleic acid, extending the primer, and inactivating the sample post-incubation. The method also involves purifying the sample before detection, ensuring accurate results. The synthetic nucleic acid and primer can have varying lengths and may contain multiple detectable labels. The method can be used with various detectable labels such as fluorescent, radioactive, chemiluminescent, or dye labels. Additionally, a kit is provided containing the necessary components for performing the method, along with detailed instructions for implementation, making it user-friendly and accessible for researchers in the field.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
