SomaLogic. has filed a patent for structures and methods to detect analyte molecules in samples using supramolecular structures. The structures are designed to minimize cross-reactivity and shift from unstable to stable states upon interaction with analytes, providing a DNA signal for detection and quantification. GlobalData’s report on SomaLogic gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on SomaLogic, Molecular diagnosis biomarkers was a key innovation area identified from patents. SomaLogic's grant share as of January 2024 was 45%. Grant share is based on the ratio of number of grants to total number of patents.
Analyte molecule detection using supramolecular structures
A recently filed patent (Publication Number: US20240027433A1) describes a method for detecting analyte molecules in a sample using a supramolecular structure. The method involves providing a structure with core molecules, a capture molecule, and a detector molecule in an unstable state. Upon contact with the sample, the structure shifts to a stable state by binding to the analyte molecule, forming a link between the detector and capture molecules. A trigger is then provided to cleave the link between the detector molecule and the core structure, allowing for the detection of the analyte molecule based on a signal provided by the supramolecular structure.
The patent also details the composition and arrangement of the core molecules, capture molecule, and detector molecule within the supramolecular structure. Various configurations are described, including the use of nucleic acid strands, peptides, and specific linker molecules to facilitate the detection process. Additionally, the patent discusses the use of triggers, such as deconstructor molecules, to initiate the detection process. The method allows for the simultaneous detection of multiple analyte molecules through multiplexing, with each supramolecular structure designed to bind to specific types of analytes. The substrate for detecting analyte molecules is also described, highlighting the use of solid supports or polymer matrices to house the supramolecular structures. Overall, the patent outlines a novel approach to detecting analyte molecules in samples using supramolecular structures with specific compositions and configurations.
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