US-based biotechnology company Fluxion Biosciences has introduced its new imaging system, the IsoFlux Cytation Imager for automated Circulating tumour cells (CTCs) analysis.

Designed to operate exclusively with the IsoFlux Liquid Biopsy System and CTC Enumeration Kit, the IsoFlux Cytation Imager is pre-configured with the required software and systems for an automated CTC image acquisition.

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Fluxion chief technical officer Dr Cristian Ionescu-Zanetti said: “This new imager can scan an entire sample in less than ten minutes, and retains the ability to detect additional protein biomarkers using a fourth fluorescence channel.

"The automated identification of putative CTCs is another big improvement, reducing the total time required per sample by over three times compared to automated microscopes."

“The automated identification of putative CTCs is another big improvement, reducing the total time required per sample by over three times compared to automated microscopes.

“Use of the IsoFlux Cytation Imager will accelerate clinical studies where CTC enumeration, protein marker detection, and cell-based analysis are important readouts.”

The IsoFlux System examines blood to perform a real-time liquid biopsy of the patient’s cancer using the recovered CTCs, which can pave the way for the analysis of DNA, RNA, and proteins.

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CTC detection by protein staining and imaging on an automated microscope has its limitations such as cost and complexity of inverted microscopes.

The new device has been developed to address these limitations by applying all components of a high-end microscope into an easy-to-use plate reader-style package.

The IsoFlux Cytation Imager features an automated stage, autofocus, high-resolution camera, three-colour fluorescence, and the required components for rapid sample scanning and image capture.

It is also fitted with an optional fluorescent channel to detect protein markers, such as AR-V7 for prostate cancer.