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August 26, 2021

Presymptom Health raises funds to expand sepsis test trial

In initial trials, the test was shown to predict sepsis onset in patients up to three days prior to the appearance of symptoms.

Presymptom Health has raised funds in a seed financing round to advance the development of its blood test for the early identification of sepsis.

The funds, from Ploughshare Innovations and UK Innovation & Science Seed Fund, will allow the government spin-out medical technology company to conclude clinical trials at various hospitals in the UK as well as progress the diagnostic test towards approval and launch.

The test is based on findings from more than ten years of research at the Defence Science and Technology Laboratory (Dstl).

In preliminary trials, the test was able to predict sepsis onset in subjects up to three days prior to symptoms appearing, allowing doctors to treat the patients earlier and manage them more efficiently.

Currently, the trial, led by doctors from Portsmouth Hospitals University NHS Trust, is progressing at Portsmouth’s Queen Alexandra Hospital.

With the latest funding, a minimum of two more trial centres are expected to be activated this year, enrolling up to 600 subjects, Presymptom noted.

The present trials will continue for 12 to 18 months. Results will be independently evaluated and utilised to refine and establish the test.

The company plans to make the sepsis test available for wider National Health Service (NHS) usage in two years.

Presymptom Health CEO Iain Miller said: “We are delighted to have reached this crucial stage and grateful to Ploughshare Innovations and UK Innovation & Science Seed Fund for their invaluable support which will enable us to maximise the impact of the trial and validate our data.

“This funding is vital to our work in confirming our test’s ability to provide early diagnosis of a disease which affects up to 49 million patients annually and causes up to 11 million deaths each year around the globe.”

Sepsis is the overreaction of the body’s immune system to an infection or damage and is linked to fatal organ dysfunction.

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